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Couplage excitation-contraction et force contractile cardiaque (Developmen - BON

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Numéro de l'objet eBay :256356920007

Dernière mise à jour : févr. 29, 2024 10:31:49 HNEAfficher toutes les modificationsAfficher toutes les modifications

Caractéristiques de l'objet

État: Bon: Un livre qui a été lu, mais qui est en bon état. La couverture présente des dommages infimes, ... Bon: Un livre qui a été lu, mais qui est en bon état. La couverture présente des dommages infimes, par exemple des éraflures, mais aucun trou ni aucune déchirure. Dans le cas des livres à reliure, la jaquette peut ne pas être incluse. La reliure présente des traces d'usure minimes. La plupart des pages ne sont pas endommagées et les plis, les déchirures, les passages soulignés ou surlignés et les inscriptions en marge sont minimes. Il n'y a aucune page manquante. Afficher toutes les définitions d'état(s'ouvre dans une nouvelle fenêtre ou un nouvel onglet)

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Book Title: Excitation-Contraction Coupling and Cardiac Contractile Force (D

MPN: Does not apply

ISBN: 9780792371588

Publication Name: Excitation-Contraction Coupling and Cardiac Contractile Force

Item Length: 9.3in

Publisher: Springer Netherlands

Publication Year: 2001

Series: Developments in Cardiovascular Medicine Ser.

Type: Textbook

Format: Trade Paperback

Language: English

Author: Donald M. Bers

Features: Revised

Item Width: 6.1in

Item Weight: 49 Oz

Number of Pages: Xxiv, 427 Pages

À propos de ce produit

Product Information

How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern 'portrait' of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction. The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure). Excitation-Contraction Coupling and Cardiac Contractile Force &e Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields.

Product Identifiers

Publisher

Springer Netherlands

ISBN-10

0792371585

ISBN-13

9780792371588

eBay Product ID (ePID)

2520711

Product Key Features

Author

Donald M. Bers

Publication Name

Excitation-Contraction Coupling and Cardiac Contractile Force

Format

Trade Paperback

Language

English

Features

Revised

Publication Year

2001

Series

Developments in Cardiovascular Medicine Ser.

Type

Textbook

Number of Pages

Xxiv, 427 Pages

Dimensions

Item Length

9.3in

Item Width

6.1in

Item Weight

49 Oz

Additional Product Features

Series Volume Number

237

Number of Volumes

1 Vol.

Lc Classification Number

Rc666-701.2

Edition Description

Revised Edition

Edition Number

Reviews

'Since the first edition of Excitation-Contraction Coupling and Cardiac Contractile Force was published 10 years ago, it has become a classic. The second edition is stunning. It retains the zest and compact form of the first edition, contains the wealth of information and analysis that has become the Bers' hallmark and is well written. It is easy and delightful to read.' W. Jonathan Lederer (excerpted from the Introduction). 'This second edition of a now classical text is both extensively revised and up-to-date. The many illustrations, a large number of which are new to this edition, supplement a clearly written text that is filled with useful information. For those who seek a lucid, comprehensive and authoritative description of the interlocked systems that control the heart beat, I know of no other source that approaches Bers' Excitation-Contraction Coupling and Cardiac Contractile Force.' Arnold M. Katz 'This book is a breath of fresh (and educated and thoughtful and well-organized) air Don Bers has produced a remarkably approachable and informative volume, clearly superior to others in this field. Active researchers should buy this book for themselves and their students.' Laurence L. Brunton, ' Since the first edition of Excitation-Contraction Coupling and Cardiac Contractile Force was published 10 years ago, it has become a classic. The second edition is stunning. It retains the zest and compact form of the first edition, contains the wealth of information and analysis that has become the Bers' hallmark and is well written. It is easy and delightful to read. ' W. Jonathan Lederer (excerpted from the Introduction). ' This second edition of a now classical text is both extensively revised and up-to-date. The many illustrations, a large number of which are new to this edition, supplement a clearly written text that is filled with useful information. For those who seek a lucid, comprehensive and authoritative description of the interlocked systems that control the heart beat, I know of no other source that approaches Bers' Excitation-Contraction Coupling and Cardiac Contractile Force . ' Arnold M. Katz ' This book is a breath of fresh (and educated and thoughtful and well-organized) air Don Bers has produced a remarkably approachable and informative volume, clearly superior to others in this field. Active researchers should buy this book for themselves and their students. ' Laurence L. Brunton

Table of Content

1. Major cellular structures involved in E-C coupling.- Sarcolemma and transverse tubules.- Extracellular space.- Sarcoplasmic reticulum.- Mitochondria.- Myofilaments.- Connections to the extracellular matrix.- Other cellular constituents.- 2. Myofilaments: The end effector of E-C Coupling.- Myofilament proteins.- Mechanism by which Ca activates contraction.- Acto-myosin ATPase.- The length-tension relationship.- The Ca sensitivity of the myofilaments.- Force-pCa relation in intact cardiac muscle.- Factors which influence the force-[Ca] relationship.- Force velocity curves.- 3. Sources and sinks of activator calcium.- General Scheme of Ca cycle in cardiac myocyte.- Cellular volume conventions and Ca fluxes.- Ca buffering in the cytosol.- Ca requirements for activation of contraction.- Ca dynamics during a twitch.- Sources and sinks of Ca.- Ca removal during relaxation.- Ca influx vs SR Ca release in contractile activation.- Mitochondrial Ca transport.- 4. Cardiac action potentials and ion channels.- Action potential & heterogeneity.- Resting Em Nernst potential & propagation.- Basic structure & function of ion channels.- Channel gating.- Na channels.- Ca channels.- K channels.- Cl channels.- Stretch-activated channels.- Non-selective channels.- Na/Ca exchange.- Na/K-ATPase.- Currents during ventricular action potential.- Pacemakers (AP Phase 4).- Early and delayed afterdepolarizations.- Reentry of excitation.- 5. Ca influx via sarcolemmal Ca channels.- Ca channel types.- Molecular characterization of Ca channels.- Ca channel selectivity and permeation.- Numbers of Ca channels.- Ca channel gating.- Amount of Ca entry via Ca channels.- Modulation of ICa by agonists and antagonists.- ?-adrenergic modulation of cardiac Ca current.- Other modulators of Ca current.- 6. Na/Caexchange and the sarcolemmal Ca-pump.- The sarcolemmal Ca-pump.- Na/Ca exchange.- Competition among Na/Ca exchange, sarcolemmal Ca-pump and SR Ca-pump during relaxation and at rest.- 7. Sarcoplasmic reticulum Ca uptake, content and release.- SR Ca-pump.- SR Ca content: Assessment in intact cardiac muscle and myocytes.- SR Ca release channel or ryanodine receptor.- 8. Excitation-contraction coupling.- Voltage-dependent Ca release (VDCR) and skeletal muscle E-C coupling.- Ca-induced Ca-release (CICR).- Local control and CICR.- Other E-C coupling mechanisms in heart.- IP3-induced Ca release (IP3ICR).- Summary.- 9. Control of cardiac contraction by SR and sarcolemmal Ca fluxes.- Species, regional and developmental differences.- Biphasic contractions.- Rest decay and rest potentiation.- Force-frequency relationships.- 10. Cardiac inotropy and Ca mismanagement.- Cardiac inotropy.- Ca mismanagement and negative inotropy.- Sites for induction of cardiac inotropy.- Conclusion.- References.

2001

Topic

Cardiology

Dewey Decimal

612.171

Intended Audience

Scholarly & Professional

Dewey Edition

Illustrated

Yes

Genre

Medical

Description de l'objet du vendeur

Le vendeur assume l'entière responsabilité de cette annonce.

Numéro de l'objet eBay :256356920007

Dernière mise à jour : févr. 29, 2024 10:31:49 HNEAfficher toutes les modificationsAfficher toutes les modifications

Expédition et manutention

Lieu où se trouve l'objet :

Montgomery, Illinois, États-Unis

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Canada, Mexique, États-Unis

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Afrique, Amérique centrale et Caraïbes, Amérique du Sud, Asie, Asie du Sud-Est, Barbade, Bermudes, Europe, Groenland, Guadeloupe, Guyane française, Libye, Martinique, Moyen-Orient, Nouvelle-Calédonie, Océanie, Polynésie française, Russie, Réunion, Saint-Pierre-et-Miquelon, Ukraine, Venezuela

Expédition et manutention	Chaque objet supplémentaire	À	Service	Livraison*Voir les remarques sur la livraison
Expédition sans frais	Sans frais	États-Unis	Expédition au tarif économique (USPS Media MailTM)	Livraison prévue entre le jeu. 6 juin et le mar. 11 juin à 43230
4,95 $US (environ 6,77 $C)	4,95 $US (environ 6,77 $C)	États-Unis	Expédition standard (DGM SmartMail Expedited)	Livraison prévue entre le lun. 10 juin et le ven. 14 juin à 43230
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